NFL Week 2 DFS Lineup for Sunday, September 17

Chris Lollis
By Chris LollisPublished: September 14, 2023
NFL Week 2 DFS Lineup for Sunday, September 17

We are back with the ultimate DFS lineup for Week 2. While taking some cheaper options at Quarterback and Defense, stick to the positive matchups while selecting King Henry, Deebo Samuel, and Christian Kirk.

Finally, should you keep riding the Tyreek Hill wave all the way to Foxborough? Here are a few “must plays” for DFS lineups on DraftKings.

QB Brock Purdy (SF)

Salary: $5,700

Purdy came into this season with high expectations with a full offseason studying the Kyle Shanahan offense as the QB1. With injury hindering that process, some experts and DFS lineup players were shocked at his top 10 QB performance against a tough Pittsburgh defense.

Heading into Week 2 against the division rival Rams, a team coach Shanahan has a positive record against, Purdy is a cheap play that could end up becoming a top 5 QB this week.

Given San Francisco has won 8 of their last 9 bouts against LA in the regular season, the high-octane offense led by Purdy should keep it rolling.

RB Derrick Henry (TEN)

Salary: $7,400

King Henry was more effective as a pass catcher than a runner last week in the physical battle against New Orleans. The Titans' opening home matchup against the Chargers should display some fireworks as Herbert will throw close to 300 yards while Henry should hit the 100-yard mark for the first time this season.

Brandon Staley’s run defense ranked 28th last season, so watch out for some chunk plays that will make Henry a great RB1 play in your week 2 DFS lineup.

RB Jamaal Williams (NO)

Salary: $5,400

While it was a less-than-ideal Week 1 showing for the fan favorite Williams, his 75% snap share and 20 total touches should be a positive sign. With Alvin Kamara out, Jamaal is a “must start” in all fantasy football formats, and against a poor Carolina defense in Week 2, he becomes our favorite RB2 play of the week.

The Panthers just let the Falcons run wild on them, as Bijan Robinson and Tyler Allgeier combined for 130 rush yards and 3 total TDs. With the potential for an extremely positive game script, take Williams to make an impact this week as New Orleans looks to start 2-0.

WR Tyreek Hill (MIA)

Salary: $8,800

After last week’s performance, you just have to bite the bullet on the salary and ride with Hill. Tyreek Hill put the entire Chargers defense in a blender last week and it’s unsure if that unit has recovered from such a dominant showing on the other side of the football.

Hill’s 15 targets on just a 66% snap share is a fantastic sign to start him again in Week 2 against the Patriots, who have a tougher defense than LAC, but just allowed some solid fantasy output to A.J. Brown and Devonta Smith.

With Tyreek’s big-play ability still intact at 29 years old, he’s a weekly add in DFS lineups at the moment.

WR Josh Reynolds (DET)

Salary: $3,700

Our flier of the week is Josh Reynolds of the Detroit Lions. The longtime Jared Goff supporter racked up 80 yards on four catches in Week 1, and should continue to be Goff’s number two option on the outside.

Expecting a bump up from his 70% snap share due to Marvin Jones’ struggles and the lack of perimeter options in this offense, he’s a great WR3 as the Lions take on Seattle who just allowed 334 pass yards to Matt Stafford.

WR Deebo Samuel (SF)

Salary: $5,600

I’m all in on Deebo Samuel in Week 2. The “Ram Killer” has averaged 101 receiving yards in five regular season games against the opponent and is a cheaper play this week as Brandon Aiyuk stole the show in Week 1.

Deebo, CMC, or Aiyuk is a “must add” to the lineup if your QB is Brock Purdy and vice-versa. While his salary remains below $6,000 on DraftKings, take Deebo as your WR2 in a game he’s bound to dominate on the ground and through the air.

TE Evan Engram (JAX)

Salary: $4,800

Tight ends are becoming increasingly difficult to predict and confidently roster in DFS lineups and fantasy football leagues. High volume, red zone work, and a high floor are the three main components I’m looking at when selecting a TE.

Evan Engram of the Jags hits these three factors as one of the least TD-dependent tight ends in fantasy football. Kansas City is typically solid against opposing tight ends, but with an added focus on Ridley in this game, Engram could have value as a check-down player and on 3rd downs.

FLX Christian Kirk (JAX)

Salary: $5,100

Buy low on Christian Kirk. Kirk had a less-than-ideal start to the season, catching just one of three targets playing in 60% of snaps. This was his worst performance in virtually every statistical category as a Jacksonville Jaguar.

That’s why Week 2 has to be different. Playing against Steve Spagnuolo’s shutdown defense with Chris Jones back, expect Lawrence to get the ball out of his hands early.

This is where Christian Kirk and his elite slot play comes in, as he could lead this team in receptions just one week after Ridley looked like one of the best wideouts in football. Bank on Kirk to get back to his old ways in the slot and make a positive impact against KC.

D/ST Buccaneers (TB)

Salary: $3,200

The Bucs veteran defense returns home to take on the Chicago Bears. Per reports, the Bears were shaken by Week 1's horrific performance against the Packers, where Jordan Love outshined Justin Fields by a mile at Soldier Field.

Chicago is turnover-prone, doesn’t play well from behind, and could force things down the field in the 2nd half of this game. As a cheaper option in DFS play with a high ceiling, take Tampa to shut Fields and the Bears down on Sunday.

Chris Lollis

Chris Lollis

Chief Content Officer

Chris Lollis, the visionary behind EatWatchDraft, serves as its principal editor. His journey spans over a decade in the sports betting realm, capturing key moments from the overturning of PASPA to the advent of sports wagering across numerous states. Chris enriches EWD with his creation of in-depth guides, insightful reviews, and strategic betting recommendations.